Q. For fighting breast cancer, is there any problem taking DIM along with Arimidex? -Tami
Hi Tami,
You big tease. Throwing out such a question just gets me fired up because the biochemistry of breast cancer cell function is a fascinating tale of good versus evil. I’ll try not to bore you but the answer is more involved than yes or no. If a yes or no answer is all you seek then your answer is yes DIM has much to offer in conjunction with Arimidex. They work by different mechanisms and would compliment each other. Now if you are a true geek (like me) read on.
A breast cancer cell simulates its own source of estrogen to help it grow. A cancer cell creates inflammation which triggers your bodies immune system to respond with IL-6 cytokine production. This inflammatory cytokine in the case of an infection is helpful part of your immune response but in the case of a cancer cell actually causes some problems. IL-6 causes the production of three enzymes. The first is aromatase which converts testosterone into estradiol, your most active estrogen. Aromatase also converts androstenedione into estrone, a weaker estrogen. Obviously any estrogen will work to stimulate cancer growth. The next enzyme that IL-6 stimulates is estrone-sulfatase which takes stored, relatively harmless estrone and cleaves of the sulfatase component making it an active estrone. Estrone is a weak estrogen but then the third enzyme that gets stimulated is 17BHSD which turns this weak estrone back into estradiol, the strongest, most active estrogen. So the cancer is inducing the production of estrogen from cells right there in its own neighborhood. It doesn’t use the ovaries or the adrenal gland to do any of this. Three enzymes leading to greater pools of estrogen to stimulate cancer and Arimidex only blocks one of them.
So the only thing that the Arimidex is doing is blocking aromatase enzyme so it’s decreasing estradiol production from testosterone but it’s not doing a thing to stop the other two sources of estrogen production. The body needs to clear out this estrogen to keep the levels as small as possible. Thats where DIM comes in. Your body has a natural process to convert estradiol back to estrone and then clear estrone out of the body by binding it up in the liver and putting it into the stool for removal from the body. Once the body converts estradiol into estrone it has the option of going down a “good” pathway (2-hydroxy) where it is converted into a beneficial product and is harmless in the cancer department.
OR it can go down a “bad” pathway (4-hydroxy) where it is converted into a carcinogen and stimulates the potential for more cancer. Obviously we want to facilitate the bodies ability to drain estrogen out of the system via the good 2-hydroxy pathway and this is what DIM does. DIM accelerates our bodies ability to clear estrogen via the healthy 2-hydroxy pathway. Think of it as drilling holes in the bottom of your estrogen bucket so that your estrogen stores don’t overflow. Other helpers that push estrone down the 2-hydroxy path are berries, soy, cruciferous vegetables, flax seed, rosemary and exercise.
Should we stop there? Hell no. Lets eat flax seed so that we can bind estrogen in the intestines and pull it out of the body. Did you know that certain bacteria in the bowel will produce estrogen right in your intestines? Great news for cancer cells everywhere, so our gut health, as always, remains very important.
Here is a list of items that block your effective use of the ever important 2-hydroxy pathway: sugar, omega 6 fats (vegetable oils), birth control pills. Lets block the 4-hydroxy (evil) pathway instead with: bioflavonoids such as green tea, dark chocolate, fruit, berries.
So there you go a simple explanation to your question. I know, you’re now sorry you asked but you are also now smarter about breast health than most doctors who are treating it.
Thanks,
Dr. Gary Huber
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4 Responses to “Q. For fighting breast cancer, is there any problem taking DIM along with Arimidex? -Tami”Speak Your Mind
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Great information. Soy can enhance the removal of bad estrogen? What else can block pathway of 2 hydroxy?
Hi Brenda,
I don’t presently know of any other factors that “block” the 2 hydroxy pathway. The question you want to consider is what will advance the 4-hydroxy pathway? That answer is “toxins” in general and our need to remove as much “junk” from our diet and our lives as possible. This is where an ounce of prevention my result in many pounds of cure.
I think you might enjoy a precious article I wrote entitled, “Fighting Disease, By The Narrowest of Margins”. I addresses this mentality.
Thanks Brenda,
Dr. Gary Huber
I had just heard of DIM and thought, I’ll see if I find answers to this product. And here you are. Great info! I had stage I hormone receptor cancer over a year ago. An Oncotype test came back as a 14 out of 100. After I had read everything about Arimidex, I talked to my radiation oncologist about the percentage points by which I would improve the recurrence scale. It was about 3 %, so, since I read and read about the side effects of Arimidex, I made the decision not to take this medication.
Instead, I increased my exercise and intake of all the good vegis and fruit and am hoping for the best. I am a 70-year old, very active woman and hate medication. Unfortunately, I used Premarin for over 25 years, since my gynecologist always promoted the good effect of Premarin. I was always a bit concerned and brought it up every year to him. It is comical that I would ultimately come done with breast cancer.
Of course, the so-called withdrawel effect of discontinuing Premarin is awful.
I think I will order DIM, I like the explanation. Thank you!
Hi Sigrid,
I glad this information is of some help to you. Look for 150 to 300 mg of DIM from a reputable manufacturer. Your doctor can assist you by measuring your estrogen levels. Also I would recommend bio-identical progesterone as a cream or as a prescription oral capsule. Progesterone is protective of the breast tissue and has been shown to arrest the growth of breast cancer in the G-1 stage of replication.
Read my breast health E-Book on this website, it’s free, and understand the importance of keeping sugar and insulin to a minimum as these things feed cancer cells in general. Get rid of as much plastic exposure in your life as possible as it contains BPA, a harmful chemical, that increases cancer potential.
You’re obviously a smart woman who knows how to care for herself and this will serve you well as you move forward in reclaiming your own health agenda.
Be well,
Dr. Gary Huber